I'm in the area where the Russian truck is driving around shooting at me. Is there a way to blow up the truck or shoot the guy in back of it???

All right I just completed The Jeep Trek!
I didn't blow up that annoying truck, but I found out that you can take the gas tank off the back of Indy's jeep and probably do something explosive with it.
Use your map to take the jeep to where you need to be. It's pretty good to go on foot to clear out areas with guys on foot.